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KMID : 0383619920130000147
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Bulletin of Environmental Sciences
1992 Volume.13 No. 0 p.147 ~ p.157
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Effects of glucocorticoid on proliferation,production of interleukin 2(IL-2) and on expression of IL-2 receptors in lymphocytes
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김정목/Kim, Jung-Mogg
조양자/이수영/박장환/Cho, Yang-Ja/Lee, Soo-Young/Park, Chang-Hwan
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Abstract
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Glucocorticoids are widely used as therapeutic agents in as variety of allergic and inflammatory diseases and in transplantation rejection. Although glucocorticoids are thought to influence on the immunologic reation, they are not fully known to influence on the immune cell function. In this report, we have studies effects of glucocorticoid. dexamethasone, on porliferation and production of interleukin-2(IL-2) in mouse splenic lymphocytes and on expression of IL-2 production, we isolated C57BL6 mice splenic cells and stimulated with Con-A(5㎍/ml). As the concentration of dexamethasone was increased, the proliferation and the IL-2 production of mouse splenic lymphocytes stimulated by Con-A (5㎍/ml) were decreased. And the expression of IL-2 receptors in human peripheral blood lymphocytes was also decreased in addition of dexamethasone.
These findings suggest that proliferation, IL-2 production, and IL-2 receptor expression of immune cells are inhibited by glucocorticoid, dexamethasone.
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KEYWORD
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